Triptorelin

Triptorelin Peptide

Triptorelin is a synthetic, high-affinity decapeptide analog of gonadotropin-releasing hormone (GnRH), which is also designated as luteinizing hormone-releasing hormone (LHRH). The compound is structurally enhanced to ensure maximum receptor binding and significantly extended metabolic resistance compared to the endogenous hormone. Triptorelin functions as a potent agonist, selectively targeting the GnRH receptors on the anterior pituitary gonadotroph cells. This binding initially triggers a robust, though transient, release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Critically, sustained, continuous exposure to Triptorelin induces a profound, predictable regulatory mechanism: prolonged receptor desensitization followed by widespread downregulation. This reliable biphasic action leads to the powerful and chronic suppression of gonadotropin release. Triptorelin is therefore an indispensable research compound for in-depth investigation into the control of the hypothalamic–pituitary–gonadal (HPG) axis, the mechanisms of pituitary down-regulation, and critical models in reproductive and oncology endocrinology.

Triptorelin Peptide - 2mg Overview

Triptorelin is a second-generation synthetic analog of GnRH, specifically designed to resist rapid systemic clearance. Its structural integrity and superior activity are rooted in two key amino acid engineering changes: the substitution of the residue at position 6 with the highly stable, non-natural stereoisomer D-tryptophan, and the substitution of the C-terminal glycine with an ethylamide group. These targeted molecular adjustments substantially improve the molecule's resistance to enzymatic proteolysis and dramatically enhance its binding stability and intrinsic potency at the GnRH receptor site.

Preclinical research confirms that Triptorelin possesses greater biological potency and a considerably longer plasma half-life when compared to native GnRH and older analogs, such as Buserelin. This compound is widely employed in experimental endocrinology for precise investigations into the functional dynamics and suppressive effects on the HPG axis. Its reliable hormonal suppression profile makes it an essential tool in research models focusing on puberty modulation protocols, the molecular mechanisms of fertility control, and the study of endocrine manipulation in various hormone-dependent tumor models.

Triptorelin Peptide Structure

Triptorelin is a decapeptide defined by the molecular formula C64H82N18O13 and a molecular weight of 1311.45 grams/mol. Its structural modifications are crucial for its extended pharmacological efficacy.

The primary amino acid sequence (structure solution formula) is precisely:

pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH-C2H5

Triptorelin Peptide Research

Triptorelin functions as a powerful tool in advanced research, allowing for the controlled manipulation of the neuroendocrine axis through its biphasic action.

Pituitary and Gonadal Axis Regulation

Triptorelin's selective interaction with the GnRH receptors facilitates the study of endocrine feedback. The initial stimulatory surge is quickly superseded by the compound's ability to induce profound receptor desensitization and downregulation. This sustained inhibitory phase creates a controlled research model of reversible hypogonadotropic hypogonadism, which is invaluable for investigating systemic feedback regulation and the effects of prolonged hormonal withdrawal.

Reproductive and Fertility Research

In reproductive studies, Triptorelin is used to modulate the hormonal environment with high precision. Pulsatile (intermittent) administration protocols are used to mimic the crucial natural release pattern of GnRH required to maintain normal gametogenesis (spermatogenesis and ovulation). Conversely, continuous administration is utilized to establish a stable model of reproductive inhibition through chronic gonadotropin suppression, allowing for the isolated study of sex steroid-dependent processes.

Endocrine and Tumor Biology

The compound's effectiveness in achieving suppression of gonadal steroid production is essential for oncology research. Triptorelin is widely employed in experimental models of androgen-dependent prostate cancer and estrogen-receptor-positive breast cancer. These investigations are critical for advancing knowledge of endocrine deprivation pathways and evaluating novel strategies for regulating hormone-dependent tumor growth.

Pubertal and Neuroendocrine Studies

In developmental neuroendocrinology, Triptorelin is a fundamental reference compound used to study the complex cascade controlling pubertal onset. It enables researchers to investigate the activity of the hypothalamic GnRH pulse generator, the developmental changes in pituitary receptor sensitivity, and the molecular mechanisms of receptor desensitization in neuroendocrine pathways.

Pharmacokinetics

Triptorelin benefits from its engineered structural stability, exhibiting a higher intrinsic binding affinity for the GnRH receptor and a significantly reduced plasma clearance rate compared to the native hormone. These combined pharmacokinetic advantages ensure a sustained and predictable biological efficacy, making it an optimal choice for chronic suppression studies.

Research Peptide Summary

This product is strictly manufactured and supplied exclusively for non-clinical, in-vitro laboratory research. It is not intended or approved for human, veterinary, diagnostic, or therapeutic use under any circumstances.

Feature

Description

Peptide Name

Triptorelin

Peptide Classification

GnRH (LHRH) Decapeptide Analog

Purity Assurance

High Purity (>98%) confirmed via HPLC

Reconstitution Protocol

Requires Bacteriostatic Water (BW)

Primary Endocrine Effect

GnRH Agonism leading to Receptor Downregulation

Research Applications

HPG Axis, Tumor Models, Reproductive Control, Pituitary Studies

Molecular Formula

C64H82N18O13

Molecular Weight

1311.45 g/mol

Supplied State

Lyophilized Powder

Storage and Handling Instructions

Adherence to strict storage and handling protocols is mandatory for maintaining the Triptorelin peptide's integrity, purity, and biological activity, which is essential for accurate and reproducible research results.

General Storage Instructions

• Lyophilized Stability: The product is delivered as a stable lyophilized (freeze-dried) powder, which is robust for short-term transit.
• Short-Term Storage: For immediate use or storage up to a few months, the lyophilized peptide should be kept refrigerated at temperatures below 4 degrees C (39 degrees F) in a tightly sealed, light-protected container.
• Long-Term Storage: For extended preservation (multiple months to years), the lyophilized powder must be stored frozen at -20 degrees C or -80 degrees C (-112 degrees F). Freezing minimizes chemical degradation.

Best Practices for Handling

• Aliquoting: To prevent structural damage caused by repeated freeze-thaw cycles, the entire product should be divided into smaller, single-use aliquots immediately upon receipt, before being placed into long-term storage.
• Moisture Prevention: The peptide is highly sensitive to moisture. Always allow the sealed vial to warm completely to room temperature before opening to prevent condensation from contaminating the hygroscopic powder.
• Air Exposure: The time the container is open to the atmosphere must be strictly minimized. Promptly and securely reseal the vial after dispensing the required powder.
• Freezer Warning: Do not use frost-free freezers for long-term storage, as their automated defrost cycles introduce destabilizing temperature fluctuations.

Storing Peptides in Solution

Peptide solutions are significantly less stable than the lyophilized powder and are highly susceptible to chemical and microbial degradation.

• Reconstitution: Once reconstituted (typically with bacteriostatic water), the solution must be stored refrigerated at 4 degrees C (39 degrees F), where its stability is generally limited to 30 days.
• Sensitive Residues: Peptides containing easily oxidizable residues, such as Cysteine (C), Methionine (M), or Tryptophan (W), require minimal liquid storage time and should be handled with extreme care.

Peptide Storage Containers

Appropriate storage vessels are necessary for maintaining purity.

• Material: High-quality glass vials offer superior chemical inertness and are preferred for all storage. Polypropylene or polystyrene vials may be used for short-term handling.