BPC-157 + TB-500

BPC-157 + TB-500 Peptide Blend (Research Use Only)

Intended Use:
This product is a research-only peptide blend containing BPC-157 and TB-500 (Thymosin Beta-4 fragment). It is supplied exclusively for laboratory investigation, including in vitro and approved in vivo animal studies.
Not for human consumption, medical, or veterinary use.

Product Overview

This dual-peptide formulation is designed for studies requiring concurrent modulation of:

• Tissue repair and remodeling
• Inflammation and immune signaling
• Angiogenesis and microvascular support

By combining BPC-157 and TB-500 in a single vial, the blend reduces logistical complexity associated with handling and dosing two separate peptides.

Component Summary

BPC-157

• Synthetic pentadecapeptide modeled on a gastric “Body Protection Compound”
• Reported in preclinical studies to:
• Regulate nitric oxide (NO) signaling via iNOS/eNOS
• Influence VEGF and related angiogenic pathways
• Modulate pro- and anti-inflammatory cytokine output
• Frequently investigated in:
• Gastrointestinal injury and ulcer models
• Tendon, ligament, and muscle repair
• Neurovascular and CNS injury paradigms
• Models examining fibrosis vs. organized regeneration

TB-500 (Thymosin Beta-4 Fragment)

• Synthetic peptide derived from thymosin beta-4
• Key mechanisms in preclinical research:
• Actin sequestration, influencing:
• Cell motility and chemotaxis
• Cell division and spreading
• Transcriptional modulation of:
• NF-κB, TLR, TNF-α, IL-1 (inflammatory cascades)
• PI3K/Akt/eNOS, Notch, Ang-1/Tie2 (angiogenesis/repair)
• TGF-β signaling (fibrosis and scarring)
• Wnt-related pathways (hair/skin biology)
• Commonly used to study:
• Wound closure kinetics and re-epithelialization
• Microvascular repair and angiogenesis
• Modulation of fibrotic tissue deposition

Rationale for Combined Use

The BPC-157 + TB-500 blend enables exploration of interacting biological networks:

• Inflammation Regulation
• BPC-157: Mediator-level control of NO and cytokines
• TB-500: Gene-level suppression of NF-κB/TLR-driven inflammatory responses
• Tissue Repair
• TB-500: Initiates cell recruitment and proliferation at damage sites
• BPC-157: Supports growth factor activity, angiogenesis, and collagen organization
• Chronic & Age-Related Models
• Studies of chronic inflammation, repetitive microtrauma, and inflammaging
• Assessment of healing quality (fibrosis vs. functional tissue) under dual-peptide exposure

Applications

Suitable for preclinical research on:

• Musculoskeletal and connective tissue injury
• Wound healing under inflammatory or ischemic stress
• Age-related decline in healing rate and tissue quality
• Comparative studies of combination vs. single-peptide protocols
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